Brain activation pattern related to gait disturbances in Parkinson's disease.
Identifieur interne : 000E69 ( Main/Exploration ); précédent : 000E68; suivant : 000E70Brain activation pattern related to gait disturbances in Parkinson's disease.
Auteurs : Julien Crémers [Belgique] ; Kevin D'Ostilio ; Julien Stamatakis ; Valérie Delvaux ; Gaëtan GarrauxSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Aged, Brain (blood supply), Brain (pathology), Brain Mapping, Female, Gait Disorders, Neurologic (etiology), Gait Disorders, Neurologic (pathology), Gait Disorders, Neurologic (rehabilitation), Humans, Image Processing, Computer-Assisted, Imagery (Psychotherapy) (methods), Magnetic Resonance Imaging, Male, Middle Aged, Oxygen (blood), Parkinson Disease (complications).
- MESH :
- chemical , blood : Oxygen.
- blood supply : Brain.
- complications : Parkinson Disease.
- etiology : Gait Disorders, Neurologic.
- methods : Imagery (Psychotherapy).
- pathology : Brain, Gait Disorders, Neurologic.
- rehabilitation : Gait Disorders, Neurologic.
- Aged, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged.
Abstract
Gait disturbances represent a therapeutic challenge in Parkinson's disease (PD). To further investigate their underlying pathophysiological mechanisms, we compared brain activation related to mental imagery of gait between 15 PD patients and 15 age-matched controls using a block-design functional MRI experiment. On average, patients showed altered locomotion relatively to controls, as assessed with a standardized gait test that evaluated the severity of PD-related gait disturbances on a 25-m path. The experiment was conducted in the subjects as they rehearsed themselves walking on the same path with a gait pattern similar as that during locomotor evaluation. Imagined walking times were measured on a trial-by-trial basis as a control of behavioral performance. In both groups, mean imagined walking time was not significantly different from that measured during real gait on the path used for evaluation. The between-group comparison of the mental gait activation pattern with reference to mental imagery of standing showed hypoactivations within parieto-occipital regions, along with the left hippocampus, midline/lateral cerebellum, and presumed pedunculopontine nucleus/mesencephalic locomotor area, in patients. More specifically, the activation level of the right posterior parietal cortex located within the impaired gait-related cognitive network decreased proportionally with the severity of gait disturbances scored on the path used for gait evaluation and mental imagery. These novel findings suggest that the right posterior parietal cortex dysfunction is strongly related to the severity of gait disturbances in PD. This region may represent a target for the development of therapeutic interventions for PD-related gait disturbances.
DOI: 10.1002/mds.25139
PubMed: 23008169
Affiliations:
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Valerie" sort="Delvaux, Valerie" uniqKey="Delvaux V" first="Valérie" last="Delvaux">Valérie Delvaux</name></author><author><name sortKey="Garraux, Gaetan" sort="Garraux, Gaetan" uniqKey="Garraux G" first="Gaëtan" last="Garraux">Gaëtan Garraux</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.25139</idno><idno type="RBID">pubmed:23008169</idno><idno type="pmid">23008169</idno><idno type="wicri:Area/PubMed/Corpus">000C37</idno><idno type="wicri:Area/PubMed/Curation">000C37</idno><idno type="wicri:Area/PubMed/Checkpoint">000F23</idno><idno type="wicri:Area/Ncbi/Merge">003825</idno><idno type="wicri:Area/Ncbi/Curation">003825</idno><idno type="wicri:Area/Ncbi/Checkpoint">003825</idno><idno type="wicri:Area/Main/Merge">000F13</idno><idno type="wicri:Area/Main/Curation">000E69</idno><idno type="wicri:Area/Main/Exploration">000E69</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Brain activation pattern related to gait disturbances in Parkinson's disease.</title><author><name sortKey="Cremers, Julien" sort="Cremers, Julien" uniqKey="Cremers J" first="Julien" last="Crémers">Julien Crémers</name><affiliation wicri:level="1"><nlm:affiliation>Movere Group, Cyclotron Research Center, University of Liège, Liège, Belgium. julien.cremers@ulg.ac.be</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Movere Group, Cyclotron Research Center, University of Liège, Liège</wicri:regionArea><wicri:noRegion>Liège</wicri:noRegion></affiliation></author><author><name sortKey="D Ostilio, Kevin" sort="D Ostilio, Kevin" uniqKey="D Ostilio K" first="Kevin" last="D'Ostilio">Kevin D'Ostilio</name></author><author><name sortKey="Stamatakis, Julien" sort="Stamatakis, Julien" uniqKey="Stamatakis J" first="Julien" last="Stamatakis">Julien Stamatakis</name></author><author><name sortKey="Delvaux, Valerie" sort="Delvaux, Valerie" uniqKey="Delvaux V" first="Valérie" last="Delvaux">Valérie Delvaux</name></author><author><name sortKey="Garraux, Gaetan" sort="Garraux, Gaetan" uniqKey="Garraux G" first="Gaëtan" last="Garraux">Gaëtan Garraux</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain (blood supply)</term><term>Brain (pathology)</term><term>Brain Mapping</term><term>Female</term><term>Gait Disorders, Neurologic (etiology)</term><term>Gait Disorders, Neurologic (pathology)</term><term>Gait Disorders, Neurologic (rehabilitation)</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Imagery (Psychotherapy) (methods)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Oxygen (blood)</term><term>Parkinson Disease (complications)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Oxygen</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Imagery (Psychotherapy)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" qualifier="rehabilitation" xml:lang="en"><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gait disturbances represent a therapeutic challenge in Parkinson's disease (PD). To further investigate their underlying pathophysiological mechanisms, we compared brain activation related to mental imagery of gait between 15 PD patients and 15 age-matched controls using a block-design functional MRI experiment. On average, patients showed altered locomotion relatively to controls, as assessed with a standardized gait test that evaluated the severity of PD-related gait disturbances on a 25-m path. The experiment was conducted in the subjects as they rehearsed themselves walking on the same path with a gait pattern similar as that during locomotor evaluation. Imagined walking times were measured on a trial-by-trial basis as a control of behavioral performance. In both groups, mean imagined walking time was not significantly different from that measured during real gait on the path used for evaluation. The between-group comparison of the mental gait activation pattern with reference to mental imagery of standing showed hypoactivations within parieto-occipital regions, along with the left hippocampus, midline/lateral cerebellum, and presumed pedunculopontine nucleus/mesencephalic locomotor area, in patients. More specifically, the activation level of the right posterior parietal cortex located within the impaired gait-related cognitive network decreased proportionally with the severity of gait disturbances scored on the path used for gait evaluation and mental imagery. These novel findings suggest that the right posterior parietal cortex dysfunction is strongly related to the severity of gait disturbances in PD. This region may represent a target for the development of therapeutic interventions for PD-related gait disturbances.</div></front></TEI><affiliations><list><country><li>Belgique</li></country></list><tree><noCountry><name sortKey="D Ostilio, Kevin" sort="D Ostilio, Kevin" uniqKey="D Ostilio K" first="Kevin" last="D'Ostilio">Kevin D'Ostilio</name><name sortKey="Delvaux, Valerie" sort="Delvaux, Valerie" uniqKey="Delvaux V" first="Valérie" last="Delvaux">Valérie Delvaux</name><name sortKey="Garraux, Gaetan" sort="Garraux, Gaetan" uniqKey="Garraux G" first="Gaëtan" last="Garraux">Gaëtan Garraux</name><name sortKey="Stamatakis, Julien" sort="Stamatakis, Julien" uniqKey="Stamatakis J" first="Julien" last="Stamatakis">Julien Stamatakis</name></noCountry><country name="Belgique"><noRegion><name sortKey="Cremers, Julien" sort="Cremers, Julien" uniqKey="Cremers J" first="Julien" last="Crémers">Julien Crémers</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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